Thalidomide-O-amido-PEG2-C2-NH2 (TFA)
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
Product Specifications
CAS Number
[1957235-75-4]
Product Name Alternative
Cereblon Ligand-Linker Conjugates 10 (TFA) ; E3 Ligase Ligand-Linker Conjugates 24 (TFA)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/E3_Ligase_Ligand-Linker_Conjugates_24_TFA.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 150 mg/mL (ultrasonic)
Smiles
O=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F
Molecular Formula
C23H27F3N4O10
Molecular Weight
576.48
Precautions
H302, H315, H319, H335
References & Citations
[1]ARYL SULFONOHYDRAZIDES. WO 2017/176958 A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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