Trichlormethiazide

Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].

Product Specifications

CAS Number

[133-67-5]

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Trichlormethiazide.html

Purity

98.54

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=S(C1=C(Cl)C=C(C2=C1)NC(C(Cl)Cl)NS2(=O)=O)(N)=O

Molecular Formula

C8H8Cl3N3O4S2

Molecular Weight

380.66

Precautions

H317, H334

References & Citations

[1]K Yao, et al. Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in various models of acute renal failure in rats. Jpn J Pharmacol. 1994 Apr;64 (4) :281-8.|[2]J R Ballew, et al. Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension. J Hypertens. 2001 Sep;19 (9) :1601-6.