N-Nonyldeoxynojirimycin

N-Nonyldeoxynojirimycin (NN-DNJ) is a deoxynojirimycin derivative with a hydrophobic long chain. N-Nonyldeoxynojirimycin is an orally active inhibitor of acid α-glucosidase (IC50: 0.42 μM) and α-1,6-glucosidase (IC50: 8.4 μM) . N-Nonyldeoxynojirimycin has activities of inhibiting glycogen breakdown, anti-virus and anti-tumor. N-Nonyldeoxynojirimycin also has insecticidal effects, with an LD50 of 5 mM for adults of Bemisia tabaci[1][2][3][4].

Product Specifications

CAS Number

[81117-35-3]

Product Name Alternative

NN-DNJ; Nonyl-DNJ

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Flavivirus; Glycosidase; Parasite

Type

Peptides

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/n-nonyldeoxynojirimycin.html

Purity

99.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC[C@H]1N(C[C@H](O)[C@@H](O)[C@@H]1O)CCCCCCCCC

Molecular Formula

C15H31NO4

Molecular Weight

289.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Andersson U, et al. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem Pharmacol. 2004 Feb 15;67 (4) :697-705.|[2]Ranes M K. Influence of imino sugars on the growth and ganglioside content of two experimental mouse brain tumors. Boston College, 2000.|[3]Ya'kobovitz MK, et al. Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders. Insect Sci. 2016 Feb;23 (1) :59-67.|[4]Zitzmann N, et al. Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents. Proc Natl Acad Sci U S A. 1999 Oct 12;96 (21) :11878-82.