5-Aminolevulinic acid-13C-1 (hydrochloride)

5-Aminolevulinic acid-13C-1 (5-ALA-13C-1) hydrochloride is the 13C labeled 5-Aminolevulinic acid hydrochloride[1]. 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles[2][3].

Product Specifications

CAS Number

[129720-94-1]

Product Name Alternative

5-ALA-13C-1 (hydrochloride) ; δ-Aminolevulinic acid-13C-1 (hydrochloride) ; 5-Amino-4-oxopentanoic acid-13C-1 (hydrochloride)

UNSPSC

12352211

Target

Apoptosis; Autophagy; Endogenous Metabolite; Mitophagy

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-aminolevulinic-acid-13c-1-hydrochloride.html

Purity

98.0

Solubility

DMSO : 100mg/mL (ultrasonic) |H2O : 16.67mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(CC[13C](CN)=O)=O.Cl

Molecular Formula

C4 13CH10ClNO3

Molecular Weight

168.58

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7 (5) : p. 392-401.|[3]Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7 (9) : p. e44885.