TLR7 agonist 27

TLR7 agonist 27 (compound 24) is a potent TLR7 agonist with an EC50 of 238.1 nM. TLR7 agonist 27 shows weak agonistic activity against NOD2 (nucleotide-binding oligomerization domain 2) (EC50 of 6.2 μM) . TLR7 agonist 27 is a potent immunostimulant, and can be used as a vaccine adjuvant and/or immunotherapeutic[1].

Product Specifications

UNSPSC

12352005

Target

NOD-like Receptor (NLR) ; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tlr7-agonist-27.html

Smiles

COC1=C(O)C=CC(/C=C/C(NCC(N[C@H](C(N[C@@H](C(OCC)=O)CCC(NCCCCCCNC(C(C=C2)=CC=C2CN3C4=NC(OCCCC)=NC(N)=C4N=C3O)=O)=O)=O)C(C)C)=O)=O)=C1

Molecular Formula

C47H64N10O11

Molecular Weight

945.07

References & Citations

[1]Špela Janež, et al. Linker Chemistry and Connectivity Fine-Tune the Immune Response and Kinetic Solubility of Conjugated NOD2/TLR7 Agonists. Bioconjug Chem. 2024 Oct 10.