TLR7 agonist 27
Product Specifications
UNSPSC Description
TLR7 agonist 27 (compound 24) is a potent TLR7 agonist with an EC50 of 238.1 nM. TLR7 agonist 27 shows weak agonistic activity against NOD2 (nucleotide-binding oligomerization domain 2) (EC50 of 6.2 μM). TLR7 agonist 27 is a potent immunostimulant, and can be used as a vaccine adjuvant and/or immunotherapeutic[1].
Target Antigen
NOD-like Receptor (NLR); Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-27.html
Smiles
COC1=C(O)C=CC(/C=C/C(NCC(N[C@H](C(N[C@@H](C(OCC)=O)CCC(NCCCCCCNC(C(C=C2)=CC=C2CN3C4=NC(OCCCC)=NC(N)=C4N=C3O)=O)=O)=O)C(C)C)=O)=O)=C1
Molecular Weight
945.07
References & Citations
[1]Špela Janež, et al. Linker Chemistry and Connectivity Fine-Tune the Immune Response and Kinetic Solubility of Conjugated NOD2/TLR7 Agonists. Bioconjug Chem. 2024 Oct 10.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168159/TLR7-agonist-27-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168159/
Clinical Information
No Development Reported
Curated Selection
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