PBB3
PBB3 is a tracer of tau PET. PBB3 can be used to detect levels of tau protein in Alzheimer's disease and non-Alzheimer's disease[1].
Product Specifications
CAS Number
[1565796-97-5]
Product Name Alternative
PF-06651600,(2R,5S)-PF-06651600,PF-06651600 (malonate)
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Fluorescent Dye; Tau Protein
Type
Reference compound
Related Pathways
Neuronal Signaling; Others
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pbb3.html
Purity
93.06
Solubility
10 mM in DMSO
Smiles
OC1=CC=C2N=C(SC2=C1)/C=C/C=C/C3=CN=C(C=C3)NC
Molecular Formula
C17H15N3OS
Molecular Weight
309.39
Precautions
H302, H312, H332
References & Citations
[1]Maiko Ono, et al. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain. 2017 Mar 1;140 (3) :764-780.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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