MCL-1/BCL-2-IN-2
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor[1].
Product Specifications
CAS Number
[2163793-44-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl-1-bcl-2-in-2.html
Purity
99.05
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N(CCN)C(C2=CC=C(SC3=CC=C(Br)C=C3)C4=CC=CC1=C24)=O
Molecular Formula
C20H15BrN2O2S
Molecular Weight
427.31
Precautions
H302, H315, H319
References & Citations
[1]Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62 (17) :8152-8163.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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