Thymidine-13C10,15N2

Thymidine-13C10,15N2 is the 13C and 15N labeled Thymidine[1]. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[2][3][4].

Product Specifications

CAS Number

[1821188-00-4]

Product Name Alternative

DThyd-13C10,15N2; NSC-13C10,15N2

UNSPSC

12352005

Target

DNA/RNA Synthesis; Endogenous Metabolite; Orthopoxvirus

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thymidine-13c10-15n2.html

Purity

99.90

Solubility

DMSO : 50 mg/mL (ultrasonic; warming)

Smiles

O=[13C]([15N]([13C@H](O[13C@@H]1[13CH2]O)[13CH2][13C@@H]1O)[13CH]=[13C]2[13CH3])[15NH][13C]2=O

Molecular Formula

13C10H14 15N2O5

Molecular Weight

254.14

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8 (17) .|[3]FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24181 (4604) :274-5.|[4]FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24