CDK7-IN-4
CDK7-IN-4 (compound I) is a potent CDK7 (Cyclin-dependent kinase 7) inhibitor. CDK7-IN-4 shows anticancer activity. CDK7-IN-4 inhibits the in vitro growth of cancer cell lines from a variety of histologies including colon , breast , lung , ovary and stomach , in a dose dependent manner[1].
Product Specifications
CAS Number
[2326428-25-3]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk7-in-4.html
Purity
98.87
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(C1=C2N(N=C1)C(NC3CCN(CC3)C(OC4CN(CC4)C(/C=C/CN(C)C)=O)=O)=CC(C)=N2)C
Molecular Formula
C26H39N7O3
Molecular Weight
497.63
References & Citations
[1]David Andrew Coates, et al. Compounds useful for inhibiting cdk7. US20190144456A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CDK7
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Arabidopsis thaliana Probable inactive receptor kinase At5g58300 (At5g58300) , partial