KU-0060648

KU-0060648 is a dual inhibitor of PI3K and DNA-PK with IC50s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively[1].

Product Specifications

CAS Number

[881375-00-4]

UNSPSC

12352005

Hazard Statement

H301

Target

DNA-PK; mTOR; PI3K

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ku-0060648.html

Purity

99.87

Solubility

DMSO : 2.78 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=C(C2=CC=CC=C2S3)C3=C(C4=C5C(C(C=C(N6CCOCC6)O5)=O)=CC=C4)C=C1)CN7CCN(CC)CC7

Molecular Formula

C33H34N4O4S

Molecular Weight

582.71

Precautions

H301

References & Citations

[1]Munck JM, et al. Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. Mol Cancer Ther. 2012 Aug;11 (8) :1789-98.|[2]Chen MB, et al. KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms. Oncotarget. 2016 Mar 29;7 (13) :17047-59.