Ivospemin
Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers[1][2][3].
Product Specifications
CAS Number
748119-79-1
Product Name Alternative
SBP-101
UNSPSC
12352211
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ivospemin.html
Purity
99.71
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
CCNCC[C@H](O)CNCCCCNC[C@@H](O)CCNCC
Molecular Formula
C16H38N4O2
Molecular Weight
318.50
References & Citations
[1]International Nonproprietary Names for Pharmaceutical Substances (INN) .|[2]Holbert CE, et al. The Polyamine Analogue Ivospemin Increases Chemotherapeutic Efficacy in Murine Ovarian Cancer. Biomedicines. 2024 May 23;12 (6) :1157. |[3]Liu TA, et al. The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis. Int J Mol Sci. 2024 Jul 26;25 (15) :8173.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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