MC-VA-PAB-Exatecan
MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan. MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity[1].
Product Specifications
CAS Number
2680543-57-9
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC; Topoisomerase
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-va-pab-exatecan.html
Purity
99.58
Solubility
DMF : ≥ 100 mg/mL|DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O
Molecular Formula
C50H54FN7O11
Molecular Weight
948.00
References & Citations
[1]KRAIEM, et al. Treatment of cancer. WO2021151984A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNCB2303-100 1x 100 µL
Smooth Muscle Myosin Heavy Chain (SM-MHC) (MYH11/2303R), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details