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MC-VA-PAB-Exatecan

MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631) . MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity[1].

Product Specifications

CAS Number

[2680543-57-9]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mc-va-pab-exatecan.html

Purity

99.58

Solubility

DMF : ≥ 100 mg/mL|DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C=CC1=O)N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O

Molecular Formula

C50H54FN7O11

Molecular Weight

948.00

References & Citations

[1]KRAIEM, et al. Treatment of cancer. WO2021151984A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Camptothecins

Available Sizes

Curated Selection

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