KB SRC 4
KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.
Product Specifications
CAS Number
1380088-03-8
UNSPSC
12352005
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KB_SRC_4.html
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C2C(N(C3=CC=CC(C4=CN=NN4CC5=CC(C6=CC=CC=C6)=CC=C5)=C3)N=C2C7=CC=C(Cl)C=C7)=NC=N1
Molecular Formula
C32H23ClN8
Molecular Weight
555.03
References & Citations
[1]Brandvold KR, et al. Development of a highly selective c-Src kinase inhibitor. ACS Chem Biol. 2012 Aug 17;7 (8) :1393-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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