YH-306

YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization[1].

Product Specifications

CAS Number

[1373764-75-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; FAK; MMP; PI3K; Src

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yh-306.html

Purity

98.34

Solubility

DMSO : 20 mg/mL (ultrasonic; adjust pH to 1 with HCl)

Smiles

OC1=CC=C(C=C1)CC(N2CC(NC3=C4C=CC=C3)=C4CC2)=O

Molecular Formula

C19H18N2O2

Molecular Weight

306.36

Precautions

H302, H315, H319

References & Citations

[1]Dai F, et al. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19 (2) :383-95.