Guanosine 5'-triphosphate (trisodium salt)

Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1][2].

Product Specifications

CAS Number

[36051-31-7]

Product Name Alternative

5'-GTP (trisodium salt)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5_acute_-GTP-trisodium-salt.html

Purity

99.76

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=P(OP(OP(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)=O)([O])=O)(O[Na])O[Na].[Na]

Molecular Formula

C10H13N5Na3O14P3

Molecular Weight

589.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Guanosine triphosphate.|[2]Pietrangelo T, et al. Extracellular Guanosine 5'-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine. Front Pharmacol. 2018 Mar 16;9:152.