Alpha-Estradiol

Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

Product Specifications

CAS Number

[57-91-0]

Product Name Alternative

Alfatradiol; Epiestradiol; Epiestrol

UNSPSC

12352005

Hazard Statement

H341, H351, H360, H362, H410

Target

5 alpha Reductase; Bacterial; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Alpha-Estradiol.html

Purity

99.88

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 11.11 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@H](O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC2

Molecular Formula

C18H24O2

Molecular Weight

272.39

Precautions

H341, H351, H360, H362, H410

References & Citations

[1]Schriefers H, et al. Inhibition of testosterone metabolism by 17-alpha-estradiol in rat liver slices. Arzneimittelforschung. 1991 Nov;41 (11) :1186-9.|[2]Santos RS, et al. The effects of 17 alpha-estradiol to inhibit inflammation in vitro. Biol Sex Differ. 2017 Sep 6;8:30.|[3]Zhang HB, et al. 17-Alpha-estradiol ameliorating oxygen-induced retinopathy in a murine model. Jpn J Ophthalmol. 2012 Jul;56 (4) :407-15.