Kanamycin (sulfate)

Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].

Product Specifications

CAS Number

[25389-94-0]

Product Name Alternative

Kanamycin A (sulfate)

UNSPSC

12352005

Hazard Statement

H360

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Kanamycin-sulfate.html

Purity

99.96

Solubility

DMSO : < 1 mg/mL|H2O : ≥ 25 mg/mL

Smiles

OS(O)(=O)=O.O[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)([H])O[C@H](CN)[C@@H](O)[C@@H]1O

Molecular Formula

C18H38N4O15S

Molecular Weight

582.58

Precautions

H360

References & Citations

[1]YANAGISAWA K, et al. Studies on kanamycin, a new antibiotic against tubercle bacilli. I. Effect on virulent tubercle bacilli in vitro and in mice. J Antibiot (Tokyo) . 1957 Nov;10 (6) :233-5. |[2]Nishi T, et al. Experimental respiratory tract infection with Klebsiella pneumoniae DT-S in mice: chemotherapy with kanamycin. Antimicrob Agents Chemother. 1980 Mar;17 (3) :494-505. |[3]Misumi M, et al. Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation. Biochem Biophys Res Commun. 1978 Sep 29;84 (2) :358-65.|[4]Misumi M, et al. Mechanism of inhibition of translocation by kanamycin and viomycin: a comparative study with fusidic acid. Biochem Biophys Res Commun. 1980 Jan 29;92 (2) :647-54.