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(S, R, S) -AHPC-PEG3-NH2 (hydrochloride)

(S, R, S) -AHPC-PEG3-NH2 (VH032-PEG3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

Product Specifications

CAS Number

2097971-11-2

Product Name Alternative

VH032-PEG3-NH2 (hydrochloride) ; VHL Ligand-Linker Conjugates 1 (hydrochloride) ; E3 ligase Ligand-Linker Conjugates 5

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_5.html

Purity

99.01

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2.[H]Cl

Molecular Formula

C30H46ClN5O7S

Molecular Weight

656.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61 (2) :504-513.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C, protect from light, stored under nitrogen

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Von Hippel-Lindau (VHL)

Available Sizes

Frequently Asked Questions

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