DGKα-IN-2
DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC50 of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
Product Specifications
CAS Number
2648556-92-5
UNSPSC
12352005
Target
DGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dgkα-in-2.html
Purity
98.83
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(N2CCC(CC2)OC3=CC=C(C=C3)OC(F)(F)F)C4=C(C=CC=C4)N(C)C1=O)N
Molecular Formula
C23H22F3N3O4
Molecular Weight
461.43
References & Citations
[1]Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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