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Centanafadine (hydrochloride)

Centanafadine (hydrochloride) is dual norepinephrine (NE) /dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

Product Specifications

CAS Number

923981-14-0

Product Name Alternative

EB-1020 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H228, H252, H360, H400, H410

Target

Adrenergic Receptor; Dopamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Centanafadine_hydrochloride.html

Purity

99.55

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

[C@@H]12[C@@](CNC2)(C3=CC(C=CC=C4)=C4C=C3)C1.Cl

Molecular Formula

C15H16ClN

Molecular Weight

245.75

Precautions

H228, H252, H360, H400, H410

References & Citations

[1]Bymaster FP, et al. Pharmacological characterization of the norepinephrine and dopamine reuptake inhibitor EB-1020: implications for treatment of attention-deficit hyperactivity disorder. Synapse. 2012 Jun;66 (6) :522-32.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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