WRN inhibitor 4
WRN inhibitor 4 (Example 107) is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor with an pIC50 of ≥ 7. WRN inhibitor 4 can be used for the research of high mutation burden tumor[1].
Product Specifications
CAS Number
2923009-45-2
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrn-inhibitor-4.html
Purity
99.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(C2=CC=CC=C2)NC(C(C(N[C@@H]3C=CS(=O)(C3)=O)=O)=C1)=O
Molecular Formula
C16H14N2O5S
Molecular Weight
346.36
References & Citations
[1]Ashley ADAMS, et al. Cyclic vinyl sulfone compounds as wrn inhibitors. Patent. WO2023062575 A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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