(S, R, S) -AHPC-C4-NH2 (hydrochloride)
(S, R, S) -AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].
Product Specifications
CAS Number
[2245697-83-8]
Product Name Alternative
VH032-C4-NH2 (hydrochloride) ; VHL Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 28
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Protac_linker_5.html
Concentration
10mM
Purity
99.69
Solubility
DMSO : ≥ 109.6 mg/mL|H2O : ≥ 50 mg/mL
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)=O)CCCCN.[H]Cl
Molecular Formula
C27H40ClN5O4S
Molecular Weight
566.16
Precautions
H302, H315, H319, H335
References & Citations
[1]Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456 (19) 30362-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
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