Me-Tet-PEG4-NH2 (hydrochloride)

Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Product Specifications

CAS Number

[2656478-51-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/me-tet-peg4-nh2-hydrochloride.html

Purity

95.04

Solubility

Methanol : 125 mg/mL (ultrasonic)

Smiles

CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(CCOCCOCCOCCOCCN)=O.Cl

Molecular Formula

C21H33ClN6O5

Molecular Weight

484.98

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562