7-Aminoactinomycin D
Product Specifications
UNSPSC Description
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects[1][2][3].
Target Antigen
Antibiotic; Bacterial; DNA Stain; DNA/RNA Synthesis
Type
Dye Reagents
Related Pathways
Anti-infection;Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/7-Aminoactinomycin_D.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N1[C@@](C(N(C)CC(N(C)[C@@H](C(C)C)C(O[C@@H]2C)=O)=O)=O)([H])CCC1)=O)C(C)C)[C@H]2NC(C(C(C(OC3=C(C)C(N)=C4)=C5C)=NC3=C4C(N[C@@H]6C(N[C@H](C(N7[C@@](C(N(C)CC(N(C)[C@@H](C(C)C)C(O[C@@H]6C)=O)=O)=O)([H])CCC7)=O)C(C)C)=O)=O)=C(N)C5=O)=O
Molecular Weight
1270.43
References & Citations
[1]Wadkins RM, et al. Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA. Biochemistry. 1991 Oct 1;30(39):9469-78.|[2]Nadine C L Zembruski, et al. 7-Aminoactinomycin D for apoptosis staining in flow cytometry. Anal Biochem. 2012 Oct 1;429(1):79-81.|[3]Hanen Sellami, et al. Molecular detection of Chlamydia trachomatis and other sexually transmitted bacteria in semen of male partners of infertile couples in Tunisia: the effect on semen parameters and spermatozoa apoptosis markers. PLoS One. 2014 Jul 14;9(7):e98903.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-D1020/7-Aminoactinomycin-D-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-D1020/7-Aminoactinomycin-D-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
7240-37-1
Available Sizes
Curated Selection
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