Dihydrouracil
Product Specifications
UNSPSC Description
Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD)-deficient[1][2].
Target Antigen
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Dihydropyrimidine-2,4_1H,3H_-dione.html
Purity
99.95
Solubility
DMSO : 14.29 mg/mL (ultrasonic)|H2O : 6.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1CCNC(N1)=O
Molecular Weight
114.10
References & Citations
[1]Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84(12):2761-2769.|[2]Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74(6):737-744.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W012926/Dihydrouracil-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W012926/Dihydrouracil-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
504-07-4
Available Sizes
Curated Selection
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