Dihydrouracil

Dihydrouracil (5,6-Dihydrouracil), a metabolite of Uracil, can be used as a marker for identification of dihydropyrimidine dehydrogenase (DPD) -deficient[1][2].

Product Specifications

CAS Number

[504-07-4]

Product Name Alternative

5,6-Dihydrouracil

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Dihydropyrimidine-2,4_1H,3H_-dione.html

Purity

99.95

Solubility

DMSO : 14.29 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1CCNC(N1)=O

Molecular Formula

C4H6N2O2

Molecular Weight

114.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Henricks LM, et, al. Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers. Br J Clin Pharmacol. 2018 Dec;84 (12) :2761-2769.|[2]Jacobs BAW, et, al. The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases. Eur J Clin Pharmacol. 2018 Jun;74 (6) :737-744.