Aloe emodin

Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis[1]. Aloe emodin also exhibits antiviral activity that against influenza A virus[2].

Product Specifications

CAS Number

[481-72-1]

Product Name Alternative

Rhabarberone; 3-Hydroxymethylchrysazine

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Influenza Virus; mTOR

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Aloe-emodin.html

Purity

98.32

Solubility

DMSO : ≥ 20.83 mg/mL

Smiles

O=C1C2=C(C=CC=C2O)C(C3=CC(CO)=CC(O)=C13)=O

Molecular Formula

C15H10O5

Molecular Weight

270.24

Precautions

H302

References & Citations

[1]Liu K, et al. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis. 2012 Jul;33 (7) :1406-11.|[2]Li SW, et al. Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation. Eur J Pharmacol. 2014 Sep 5;738:125-32.