MIV-247
MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
Product Specifications
CAS Number
1352817-76-5
UNSPSC
12352211
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/MIV-247.html
Solubility
10 mM in DMSO
Smiles
FC1(CCCC1)C[C@H](NC(C(F)(F)C)=O)C(NC2(CCC2)C(C(N)=O)=O)=O
Molecular Formula
C17H24F3N3O4
Molecular Weight
391.39
References & Citations
[1]Hewitt E. et al. Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :387-96.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin S
Available Sizes
Frequently Asked Questions
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