MIV-247
MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively.
Product Specifications
UNSPSC
12352211
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/MIV-247.html
Solubility
10 mM in DMSO
Smiles
FC1(CCCC1)C[C@H](NC(C(F)(F)C)=O)C(NC2(CCC2)C(C(N)=O)=O)=O
Molecular Formula
C17H24F3N3O4
Molecular Weight
391.39
References & Citations
[1]Hewitt E. et al. Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :387-96.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112583/MIV-247-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112583/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin S
CAS Number
[1352817-76-5]
Available Sizes
Curated Selection
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