Scalaradial

Product Specifications

CAS Number

[53527-28-9]

UNSPSC Description

Scalaradial is an inhibitor for bee venom phospholipase A2 (PLA2) and transient receptor potential melastatin 2 (TRPM2) ion channels, with IC50 of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK, by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA (HY-18739)-induced release of Arachidonic acid (HY-109590) in the mouse peritoneal macrophage[1][2][3].

Target Antigen

Akt; ERK; Phospholipase; TRP Channel

Type

Natural Products

Related Pathways

MAPK/ERK Pathway;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/scalaradial.html

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@@](C[C@@H]([C@]3([C@@]2([H])CC=C([C@@H]3C=O)C=O)C)OC(C)=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC1)C

Molecular Weight

428.60

References & Citations

[1]Starkus JG, et al., Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels. J Nat Prod. 2017 Oct 27;80(10):2741-2750.|[2]de Carvalho MS, et al., Two-step inactivation of bee venom phospholipase A2 by scalaradial. Biochem Pharmacol. 1991 Sep 27;42(8):1621-6. |[3]Xie Y, et al., Biphasic regulation of extracellular signal-regulated kinases by scalaradial, a secretory phospholipase A(2) inhibitor. Cancer Biol Ther. 2006 Aug;5(8):988-92.