Scalaradial
Product Specifications
UNSPSC Description
Scalaradial is an inhibitor for bee venom phospholipase A2 (PLA2) and transient receptor potential melastatin 2 (TRPM2) ion channels, with IC50 of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK, by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA (HY-18739)-induced release of Arachidonic acid (HY-109590) in the mouse peritoneal macrophage[1][2][3].
Target Antigen
Akt; ERK; Phospholipase; TRP Channel
Type
Natural Products
Related Pathways
MAPK/ERK Pathway;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/scalaradial.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@](C[C@@H]([C@]3([C@@]2([H])CC=C([C@@H]3C=O)C=O)C)OC(C)=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC1)C
Molecular Weight
428.60
References & Citations
[1]Starkus JG, et al., Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels. J Nat Prod. 2017 Oct 27;80(10):2741-2750.|[2]de Carvalho MS, et al., Two-step inactivation of bee venom phospholipase A2 by scalaradial. Biochem Pharmacol. 1991 Sep 27;42(8):1621-6. |[3]Xie Y, et al., Biphasic regulation of extracellular signal-regulated kinases by scalaradial, a secretory phospholipase A(2) inhibitor. Cancer Biol Ther. 2006 Aug;5(8):988-92.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123245/Scalaradial-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123245/
Clinical Information
No Development Reported
CAS Number
53527-28-9
Curated Selection
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