CMB-087229
CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC50 of 67 nM, which can be used in the research of amyotrophic lateral sclerosis[1].
Product Specifications
CAS Number
1227692-67-2
UNSPSC
12352005
Hazard Statement
H315, H319
Target
SOD
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cmb-087229.html
Purity
98.05
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C=C(COC2=CC(Cl)=CC(Cl)=C2)NN1
Molecular Formula
C10H8Cl2N2O2
Molecular Weight
259.09
Precautions
H315, H319
References & Citations
[1]Tian Chen, et al. ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis.J. Med. Chem. 2012, 55, 1, 515–527.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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