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CMB-087229

CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC50 of 67 nM, which can be used in the research of amyotrophic lateral sclerosis[1].

Product Specifications

CAS Number

1227692-67-2

UNSPSC

12352005

Hazard Statement

H315, H319

Target

SOD

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cmb-087229.html

Purity

98.05

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=C(COC2=CC(Cl)=CC(Cl)=C2)NN1

Molecular Formula

C10H8Cl2N2O2

Molecular Weight

259.09

Precautions

H315, H319

References & Citations

[1]Tian Chen, et al. ADME-Guided Design and Synthesis of Aryloxanyl Pyrazolone Derivatives To Block Mutant Superoxide Dismutase 1 (SOD1) Cytotoxicity and Protein Aggregation: Potential Application for the Treatment of Amyotrophic Lateral Sclerosis.J. Med. Chem. 2012, 55, 1, 515–527.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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