HCAR2 agonist 1
HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1) . HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis[1].
Product Specifications
CAS Number
[1066676-21-8]
UNSPSC
12352005
Target
Hydroxycarboxylic Acid Receptor (HCAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hcar2-agonist-1.html
Purity
99.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C(N[C@H](C)COC2=CC=CC=C2)=O)C=NC3=C(C4=CC=C(C=C4)C(C)C)C=NN13
Molecular Formula
C26H28N4O2
Molecular Weight
428.53
References & Citations
[1]Zhao C, et al. Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation. Mol Cell. 2023 Sep 7;83 (17) :3171-3187.e7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HCAR2
Available Sizes
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