NCT-506
NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM[1].
Product Specifications
CAS Number
2231098-99-8
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NCT-506.html
Purity
99.95
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
FC1=CC2=C(C3=CC=C(C4(CC4)C#N)C=C3)C(C(N5CCN(S(C)(=O)=O)CC5)=O)=CN=C2C=C1
Molecular Formula
C25H23FN4O3S
Molecular Weight
478.54
References & Citations
[1]Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61 (11) :4883-4903.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1
Available Sizes
Frequently Asked Questions
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