HSD17B13-IN-94
HSD17B13-IN-94 (Compound 12) is an effective inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for Estradiol. HSD17B13-IN-94 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD, NASH, or drug-induced liver injury (DILI).
Product Specifications
CAS Number
2848620-90-4
UNSPSC
12352005
Target
17β-HSD; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hsd17b13-in-94.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C(NC2=C(C(NCCC3=C(OC)C=CC=C3)=O)N=C(C)S2)=O)C=C1Cl
Molecular Formula
C21H20ClN3O4S
Molecular Weight
445.92
References & Citations
[1]Joshua Odingo, et al. Thiazole/isothiazole hsd17b13 inhibitors and uses thereof. WIPO (PCT) . WO2022216627A1. 2022-10-13
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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