DNA Gyrase-IN-12

DNA Gyrase-IN-12 (Compound 6d) is a DNA gyrase inhibitor. DNA Gyrase-IN-12 has Antibacterial activity and MIC value of vancomycin-intermediate S. aureus (VISA) and Enterococcus faecalis strains is between 0.031 and 0.0625 μg/mL[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dna-gyrase-in-12.html

Smiles

O=C(N1CCC(NC2=CC(C(N3)=NOC3=O)=CC=C2NC(C4=C(Cl)C(Cl)=C(C)N4)=O)CC1)OC(C)(C)C

Molecular Formula

C24H28Cl2N6O5

Molecular Weight

551.42

References & Citations

[1]Zidar N, et al. Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains. Eur J Med Chem. 2024 Nov 15;278:116823.