GSK-J1 (sodium)

GSK-J1 sodium is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50 value of 60 nM towards KDM6B[1][2][3].

Product Specifications

CAS Number

[1797832-71-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Histone Demethylase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk-j1-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(CCNC1=CC(N2CCC3=C(CC2)C=CC=C3)=NC(C4=CC=CC=N4)=N1)O[Na]

Molecular Formula

C22H22N5NaO2

Molecular Weight

411.43

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488 (7411) :404-8.|[2]Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514 (7520) :E1-2.|[3]Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291 (6) :2631-46.