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Alprenolol

Alprenolol ((RS) -Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent[1][2][3].

Product Specifications

CAS Number

13655-52-2

Product Name Alternative

(RS) -Alprenolol; dl-Alprenolol

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Alprenolol.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; adjust pH to 7 with 1 M HCL; heat to 60°C) |H2O : < 0.1 mg/mL

Smiles

OC(COC1=CC=CC=C1CC=C)CNC(C)C

Molecular Formula

C15H23NO2

Molecular Weight

249.35

References & Citations

[1]Himori N, et al. Effects of beta-adrenoceptor blocking agents, pindolol, alprenolol and practolol on blood pressure and heart rate in conscious renal hypertensive dogs. Arch Int Pharmacodyn Ther. 1977 Jan;225 (1) :152-65.|[2]Fernández-Guasti A, et al. Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone. Psychopharmacology (Berl) . 1990;101 (3) :354-8.|[3]Parratt JR, et al. Myocardial and haemodynamic effects of the beta-adrenoceptor blocking drug alprenolol (H56/28) in anaesthetized cats. Br J Pharmacol. 1969 Oct;37 (2) :357-66.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

5-HT1 Receptor; mLAG-3

Citation 01

Biochemistry. 2025 Aug 19;64 (16) :3585-3598.|bioRxiv. 2020 Jan.|J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Jul 1:1227:123804.|J Pharm Biomed Anal. 2021 Feb 20:195:113870.|Nat Commun. 2020 Sep 25;11 (1) :4857.|Sci Total Environ. 2024 May 13:933:173244.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Nat Chem Biol. 2024 Jan;20 (1) :74-82.

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