LAP

LAP (Lithium phenyl-2,4,6-trimethylbenzoylphosphinate) is a free radical initiator. The free radicals produced by LAP under bioprinting conditions are potentially cytotoxic and mutagenic. In addition, the concentration of LAP affects the mechanical strength of 3D printed scaffolds. Generally, the concentration range of LAP used for curing is 0.05%-1%. The elastic modulus produced at a concentration of 0.1% is the highest, with enhanced mechanical properties and excellent biocompatibility[1][2][3].

Product Specifications

CAS Number

[85073-19-4]

Product Name Alternative

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others; Cancer

Assay Protocol

https://www.medchemexpress.com/lap.html

Purity

99.93

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=P(C(C1=C(C)C=C(C)C=C1C)=O)(C2=CC=CC=C2)O[Li]

Molecular Formula

C16H16LiO3P

Molecular Weight

294.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Nguyen AK, et al. The Photoinitiator Lithium Phenyl (2,4,6-Trimethylbenzoyl) Phosphinate with Exposure to 405 nm Light Is Cytotoxic to Mammalian Cells but Not Mutagenic in Bacterial Reverse Mutation Assays. Polymers (Basel) . 2020 Jul 3;12 (7) :1489.|[2]Qian Feng, et al. "Multi-modal imaging for dynamic visualization of osteogenesis and implant degradation in 3D bioprinted scaffolds." Bioactive Materials 37 (2024) : 119-131.|[3]Nguyen, et al. Toxicity and photosensitizing assessment of gelatin methacryloyl-based hydrogels photoinitiated with lithium phenyl-2, 4, 6-trimethylbenzoylphosphinate in human primary renal proximal tubule epithelial cells. Biointerphases 14.2 (2019) .|[4]Xu H, et al. Effects of Irgacure 2959 and lithium phenyl-2,4,6-trimethylbenzoylphosphinate on cell viability, physical properties, and microstructure in 3D bioprinting of vascular-like constructs. Biomed Mater. 2020 Aug 7;15 (5) :055021.