11 (α) -Methoxysaikosaponin F

11 (α) -Methoxysaikosaponin F is a triterpenoid saponin isolated from Bupleurum marginatum Wall.ex DC (ZYCH) which is a promising therapeutic for liver fibrosis. 11 (α) -Methoxysaikosaponin F has an IC50 of 387.7 nM with viability of hepatic stellate cells-T6 (HSCs-T6) . Triterpenoid saponins have numerous targets, important network positions, and strong inhibitory activity[1].

Product Specifications

CAS Number

[104109-37-7]

UNSPSC

12352005

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/11-alpha-methoxysaikosaponin-f.html

Purity

99.51

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@]12[C@@]([C@@H](C=C3[C@]2(C[C@H](O)[C@]4(CO)[C@@]3([H])CC(C)(C)CC4)C)OC)([H])[C@@]5([C@@](C(C)([C@@H](O[C@]6([H])O[C@@H]([C@@H](O[C@@]7([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O7)O)O)[C@H](O)[C@H]6O)CO[C@@H]8O[C@@H]([C@@H](O)[C@H](O)[C@H]8O)CO)CC5)C)([H])CC1)C

Molecular Formula

C49H82O18

Molecular Weight

959.16

References & Citations

[1]Liu X, et al. Bupleurum marginatum Wall.ex DC in Liver Fibrosis: Pharmacological Evaluation, Differential Proteomics, and Network Pharmacology. Front Pharmacol. 2018 May 17;9:524.