VX-150

VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

Product Specifications

CAS Number

[1793080-72-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vx-150.html

Purity

98.36

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C=C(NC(C2=CC=C(C(F)(F)F)C=C2OC3=CC=C(C=C3C)F)=O)C=CN1COP(O)(O)=O

Molecular Formula

C21H17F4N2O7P

Molecular Weight

516.34

Precautions

H302, H315, H319

References & Citations

[1]Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22 (8) :1814-1826.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Nav1.8

Available Sizes

Curated Selection

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