MPD2
MPD2 is a Cereblon-binding ligand-based PROTAC that degrades MPro, the main protease of SARS-CoV-2. MPD2 effectively reduced MPro protein levels in 293T cells in a time-dependent manner (DC50=296 nM). MPD2 exhibited potent antiviral activity against multiple SARS-CoV-2 strains and had enhanced potency against Nirmatrelvir resistant strains. MPD2 provides a new direction for antiviral drug development against SARS-CoV-2 and other emerging coronavirus pathogens (Sturcture Note: (Blue: Cereblon ligand (HY-14658), Black: linker (HY-W275882); Red: SARS-CoV-2 MPro Inhibitor MP18 (HY-158763) ).
Product Specifications
UNSPSC
12352005
Target
PROTACs; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mpd2.html
Smiles
O=C(OCC1=CC=CC(OCCCCCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=C1)N[C@@H]([C@H](OC(C)(C)C)C)C(N[C@@H](CC5CCCCC5)C(N[C@@H](C[C@H]6C(NCC6)=O)C=O)=O)=O
Molecular Formula
C51H68N6O13
Molecular Weight
973.12
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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