CRT0105950
CRT0105950 is a potent LIMK inhibitor, with IC50s of 0.3 nM and 1 nM for LIMK1 and LIMK2 respectively. CRT0105950 can be used for the research of cancer[1].
Product Specifications
CAS Number
1661845-86-8
UNSPSC
12352005
Target
LIM Kinase (LIMK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crt0105950.html
Purity
99.76
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C=C1)NC2=NC=C(S2)C3=C(C=NC=C3)C4=CC=C(C=C4Cl)C
Molecular Formula
C21H16ClN3OS
Molecular Weight
393.89
References & Citations
[1]Mardilovich K, et, al. LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget. 2015 Nov 17;6 (36) :38469-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LIMK1; LIMK2
Available Sizes
Frequently Asked Questions
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