Anti-SMYD2 monoclonal Antibody
Boster Bio Anti-SMYD2 monoclonal Antibody catalog # M04281. Tested in WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
N-lysine methyltransferase SMYD2;2.1.1.-; HSKM-B; Histone methyltransferase SMYD2;2.1.1.43; Lysine N-methyltransferase 3C; SET and MYND domain-containing protein 2; SMYD2; KMT3C;
Gene Name
SMYD2
UniProt
Q9NRG4
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Recombinant full length Human SMYD2.
Clonality
Monoclonal
Applications
WB
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:1000
Form
Liquid
Function
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2) . Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Molecular Weight
49688 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
N-lysine methyltransferase SMYD2
Subcellular Location
Cytoplasm, cytosol . Nucleus .
Protein Name
N-lysine methyltransferase SMYD2
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