Anti-SKIV2L2 MTREX Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly (A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly (A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484) . Associated with the RNA exosome complex and involved in the 3'- processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693) . May be involved in pre-mRNA splicing.