Anti-BAI-1 (Q732) ADGRB1 Antibody

Expressed in brain (at protein level) (PubMed:12074842, PubMed:12507886) . Expressed on mononuclear phagocytes and monocyte-derived macrophages in the gastric mucosa (at protein level) (PubMed:24509909) . Expressed in normal pancreatic tissue but not in pancreatic tumor tissue (PubMed:11875720) . Reduced or no expression is observed in some glioblastomas (PubMed:12507886) .

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909) . Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550) . Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550) . In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909) . Promotes myoblast fusion (By similarity) . Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696) . Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity) . Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity) . Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720) .