Anti-WBSCR22 BUD23 Antibody

Widely expressed, with high levels in heart, skeletal muscle and kidney. Detected at high levels in bronchial brushings and in normal lung (at protein level) . In fetal lung tissue, expressed in the developing bronchial lumen lining cells (at protein level) . Tends to be down-regulated in lungs affected by inflammatory diseases or neoplasia (at protein level) . Expressed in immune cells, including B and T lymphocytes and macrophages.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N (7) position of a guanine in 18S rRNA (PubMed:25851604) . Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604) . Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604) . Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612) . Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492) . Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492) . Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492) .