Anti-PCGF3 Antibody
Boster Bio Anti-PCGF3 Antibody catalog # A14425. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Polycomb group RING finger protein 3; RING finger protein 3A; PCGF3; RNF3, RNF3A;
Gene Name
PCGF3
UniProt
Q3KNV8
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human PCGF3.
Clonality
Polyclonal
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332) . Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity) .
Molecular Weight
28115 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Polycomb group RING finger protein 3
Subcellular Location
Nucleus
Protein Name
Polycomb group RING finger protein 3
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