Anti-GPR75 Antibody
Boster Bio Anti-GPR75 Antibody catalog # A13384-1. Tested in WB, ICC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
Probable G-protein coupled receptor 75; GPR75;
Gene Name
GPR75
UniProt
O95800
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 423-468 of Human GPR75.
Clonality
Polyclonal
Tissue Specificity
Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level) .
Applications
WB, ICC
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Form
Liquid
Function
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Molecular Weight
59359 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Probable G-protein coupled receptor 75
Subcellular Location
Cell membrane; Multi-pass membrane protein .
Protein Name
Probable G-protein coupled receptor 75
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