Anti-DNAJB9 Antibody
Boster Bio Anti-DNAJB9 Antibody catalog # A10053. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Synonyms
DnaJ homolog subfamily B member 9 ; Endoplasmic reticulum DNA J domain-containing protein 4
Gene Name
DNAJB9
UniProt
Q9UBS3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human DNAJB9.
Clonality
Polyclonal
Tissue Specificity
Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248) .
Applications
WB
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Dilution
WB: 1:500-1:2000
Form
Liquid
Function
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity) . J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946) . In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity) . Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity) .
Molecular Weight
25518 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
DnaJ homolog subfamily B member 9
Subcellular Location
Endoplasmic reticulum lumen
Protein Name
DnaJ homolog subfamily B member 9
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